GENERAL PHARMACOLOGY AND PHARMACOTHERAPY I
FARMACOLOGIA GENERALE E FARMACOTERAPIA I
GENERAL PHARMACOLOGY AND PHARMACOTHERAPY I
FARMACOLOGIA GENERALE E FARMACOTERAPIA I
| A.Y. | Credits |
|---|---|
| 2019/2020 | 10 |
| Lecturer | Office hours for students | |
|---|---|---|
| Piero Sestili | The lecturer meets the students at the end of each lesson. |
| Teaching in foreign languages |
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Course with optional materials in a foreign language
English
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language. |
Assigned to the Degree Course
| Date | Time | Classroom / Location |
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| Date | Time | Classroom / Location |
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Learning Objectives
The aim of the course is to provide knowledge about routes of administration, metabolism, distribution, and elimination of synthetic and plant-derived drugs as well as the basic concepts of their therapeutic and adverse effects. In the second part of the course, attention will be devoted to the study of the antibiotics and chemotherapeutic drugs used in antibacteria, antiviral, antimicotic and anticancer drugs..
Program
PHARMACOLOGY: general principles: drug, medicine and poison.
Pharmacokinetics: Physicochemical factors in transfer of drugs across membranes. Drug absorption, bioavailability, and routes of administration. Distribution of drugs. Biotransformation of drugs. Excretion of drugs. Clinical pharmacokinetics.
Pharmacodynamics: Mechanisms of drug action. Drug receptors. Receptors for physiological regulatory molecules. Quantitation of drug-receptor interactions. Dose-effect relationship.
CHEMOTHERAPY
General considerations of antimicrobial therapy sulfonamides and quinolones. Beta-lactam antibiotics, penicillins and cephalosporins. Cell wall, inhibitors Aminoglycosides. Protein synthesis inhibitors. Chemotherapy of tuberculosis. Antifungal agents. Antiviral and antiretroviral agents. Antineoplastic agents. Chemotherapy of protozoal infections (malaria, amebiasis, trichomoniasis, trypanosomiasis).
Learning Achievements (Dublin Descriptors)
At the end of the course, students should demonstrate a) knowledge nd competence about drug metabolism (administration, clearance, therapeutic and adverse effects); b) a robust knowledge of the general principles of chemo-antiobiotic therapy as well as of the different class of antibiotics and chemotherapeutic agents, the different mechanisms of action and their therapeutic use in relation to type of the infection/infestion or of the type of tumor.
Teaching Material
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
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