The aim of the course is to provide knowledge about routes of administration, metabolism, distribution, and elimination of synthetic and plant-derived drugs as well as the basic concepts of their therapeutic and adverse effects. In the second part of the course, attention will be devoted to the study of the antibiotics and chemotherapeutic drugs used in antibacteria, antiviral, antimicotic and anticancer drugs..

PHARMACOLOGY: general principles: drug, medicine and poison.
Pharmacokinetics: Physicochemical factors in transfer of drugs across membranes. Drug absorption, bioavailability, and routes of administration. Distribution of drugs. Biotransformation of drugs. Excretion of drugs. Clinical pharmacokinetics.
Pharmacodynamics: Mechanisms of drug action. Drug receptors. Receptors for physiological regulatory molecules. Quantitation of drug-receptor interactions. Dose-effect relationship.

CHEMOTHERAPY

General considerations of antimicrobial therapy  sulfonamides and quinolones. Beta-lactam antibiotics, penicillins and cephalosporins. Cell wall, inhibitors  Aminoglycosides. Protein synthesis inhibitors. Chemotherapy of tuberculosis. Antifungal agents. Antiviral and antiretroviral agents.  Therapy of COVID-19. Antineoplastic agents. Chemotherapy of protozoal infections (malaria, amebiasis, trichomoniasis, trypanosomiasis).

I is highly recommended to have passed the exams of Biochemistry and Human Physiology

At the end of the course, students should demonstrate  

a robust knowledge and competence about:   a) the principles of general pharmacology; b) the principles of chemo-antiobiotic therapy c) the different classes of antibiotics and chemotherapeutic agents and their therapeutic use in relation to type of the infection/infestion or of the type of tumor. 

-the scientific backround needed to evaluate the general principles of drug use and prescription of tyhe drugs, and in particular of the classes the chemo-antibiotic agents in a professional setting.

-critical  and competent assessment capacity with regard to the issues typical of the discipline 

-effective communication skills in general pharmacology and chemo-antibiotic therapy 

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Teaching

Frontal lessons

Attendance

None

Course books

• H.P. Rang, J.M. Ritter, R.J. Flower, G. Henderson. "Farmacologia". Ottava edizione
• as an alternative: R. Levine "Farmacologia. Azioni e reazioni dei farmaci" EMSI

       Both the textbooks are available in English

Assessment

Oral exam

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Attendance

None

Course books

• H.P. Rang, J.M. Ritter, R.J. Flower, G. Henderson. "Farmacologia". Ottava edizione
• as an alternative: R. Levine "Farmacologia. Azioni e reazioni dei farmaci" EMSI

       Both the textbooks are available in English

Assessment

Oral exam

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.