Abstract dell'evento

43rd Advanced Course of Medicinal Chemistry and Seminar for PhD students

The mission of the ESMEC is to provide participants, PhD students and junior researchers from both academia and industry, with the most recent advances in the field of medicinal and organic chemistry, pharmacology, molecular biology and analytical/ structural chemistry. This idea is aimed to reflect the current scenario of medicinal chemistry being a truly transdisciplinary approach, where the advances in knowledge are driven by the medicinal chemist’s ability to translate into new molecular concepts and into novel molecular entities the amount of information created by molecular medicine, pharmacology, molecular biology, systems biology.

For these reasons, the School is directed to participants at a graduated and post-graduated level, in chemistry but also in pharmacology or biology, who are keen to explore the interdisciplinary context of current cutting-edge research in medicinal chemistry.

To achieve these very ambitious goals, the School is organized into thematic sessions, each of them constructed around a series of lectures, followed by practical workshops.

MONDAY, JULY 1

09.00 – 09.20 Opening of ESMEC 2024
Giorgio Calcagnini – Rector of the University of Urbino Carlo Bo
Luc Van Hijfte – President of the European Federation for Medicinal Chemistry and Chemical Biology
Maria Laura Bolognesi – President of the Medicinal Chemistry Division of the Italian Chemical Society
Marco Macchia – Director of the European School of Medicinal Chemistry

Make it unbreakable! covalent approach in drug discovery

Co-chair:
Andrea Cavalli – University of Bologna (I)
Gianluca Papeo – Nerviano Medical Sciences (I)

09.20 – 09.30 Introduction to the Session
09.30 – 10.15 Alessio Lodola – University of Parma (I)
Models for the discovery of covalent inhibitors

10.15 – 11.00 Chiara Borsari – University of Milan (I)
Integration of medicinal chemistry and chemical biology in the development of covalent chemical probes

11.00 – 11.30 Coffee Break

11.30 – 12.15 Annamaria MARTORANA – University of Palermo (I)
Targeting Sars-Cov-2 Main protease in the treatment of COVID-19: focus on covalent inhibition

12.15 – 13.00 Francesco CASUSCELLI – Nerviano Medical Sciences, Milan (I)
Leveraging Covalent Approaches for the Discovery and Drug Development of Dual IDH1/2 Second Generation Inhibitors

13.00 – 15.00 Lunch

15.00 – 17.00 Workshop: PICK YOUR FAVORITE ELECTROPHILE! FROM REACTIVITY SCALE TO COVALENT ADDUCT STRUCTURES
Chiara BORSARI – University of Milan (I)
Alessio LODOLA – University of Parma (I)

17.00 – 18.00 Poster Session
Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)

20.00 Dinner

21.00 Walking tour of the historic center of Urbino, UNESCO heritage site
 

TUESDAY, JULY 2

CLICK-AND-TAG: HOW BIOORTHOGONAL CHEMISTRY IS TRANSFORMING DRUG DISCOVERY

Co-chair: Stephanie FEDERICO – University of Trieste (I)
Antimo GIOIELLO – University of Perugia (I)

09.00 – 09.15 Introduction to the Session

09.15 – 10.00 Helen OSBORN – University of Reading (UK)
Designing chemical reactions for use in living systems: the role of bioorthogonal chemistry

10.00 – 10.45 Anja PALMANS – Eindhoven University of Technology (NL)
Bioorthogonal catalysis for medicinal chemistry applications

10.45 – 11.15 Coffee Break

11.15 – 12.00 Frédéric TARAN – Paris-Saclay University (F)
In vivo chemistry for diagnostic and therapeutic applications

12.00 – 12.45 Milan VRABEL – Czech Academy of Sciences, Prague (CZ)
Developing new bioorthogonal reactions: Expanding the toolbox for biomedical research

12.45 – 14.30 Lunch

14.30 – 16.00 Workshop: HOW TO TRANSLATE MEDCHEM DISCOVERIES INTO INNOVATION
Elisabetta Zaccaro – Notarbartolo & Gervasi, Milan (I)
Marco Borgogno – IAMA Therapeutics, Genoa (I)

16.00 Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI

17.00 – 18.00 Poster Session
Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)

19.45 Dinner

21.00 Guided tour of the Ducal Palace

WEDNESDAY, JULY 3

UNUSUAL ELEMENTS AND FUNCTIONAL GROUPS SHAPING THE FUTURE OF MEDICINAL CHEMISTRY

Co-chair: Paolo GRIECO – University of Naples Federico II (I)
Tracey PIRALI – University of Piemonte Orientale (I)

09.00 – 09.15 Introduction to the Session

09.15 – 10.00 Gian Cesare TRON – University of Piemonte Orientale (I)
Lost and found: (Re)discovering the potential of neglected functional groups in medicinal chemistry. A focus on isocyanides

10.00 – 10.45 Jack ROWBOTHAM – University of Manchester (UK)
Meeting the challenges of heavy drug synthesis with biocatalytic asymmetric deuteration

10.45 – 11.15 Coffee Break

11.15 – 12.00 Evamarie HEY-HAWKINS – Leipzig University (D)
Carborane-containing drugs: New keys for old locks

12.00 – 12.45 Mauro ADAMO – University of Medicine and Health Science, Dublin (IE)
Introduction of fluorine on small and large molecules: Opportunities for drug discovery and lead development

12.45 – 14.30 Lunch

14.30 – 17.00 Round Table: The Future of Medicinal Chemistry: the opinion of emerging voices (Open Webinar)

Chairperson: Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society

Participants: Chiara BORSARI – Università degli Studi di Milano (I)
Matthias GEHRINGER – Eberhard Karls Universität Tübingen (D)
Luca LARAIA – Technical University of Denmark (DE)
Sebastian OEHLER – Philochem AG (CH)
Andrea TESTA – Amphista Therapeutics Limited (UK)

Beatriz DE PASQUAL-TERESA – University CEU San Pablo, Madrid (E)

17.00 – 17.30 Fourth Edition of the ESMEC Alumni Award (Open Webinar)

Chairperson: Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society

20.30 Social Dinner

THURSDAY, JULY 4

Chairperson: Beatriz DE PASQUAL-TERESA, University CEU San Pablo, Madrid (E)

09.00 – 10.00 Tiziano BANDIERA – Istituto Italiano di Tecnologia, Genoa (I)
Market watch: new drug approval in 2023 and synthetic strategies

10.00 – 10.30 Coffee Break

10.30 – 10.45 Michele MARI – University of Urbino Carlo Bo (I)
EFMC-YSN: join the young scientists network!

10.45 – 12.45 Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
Selected oral lectures by participants

12.45 – 13.15 Marco MACCHIA – University of Pisa (I) – Director of ESMEC
Awards of selected posters
Concluding remarks

13.15 Lunch and leaving