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Assigned to the Degree Course
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The morphological, metabolic and genetic characterization of microorganisms is the educational objective of the first part of the course.
The study of some human pathogens and the virus characterization are the educational goals of the second part of the course.
The various features of microrganisms-environment and microrganisms-human host interactions are the educational goals of the final part of the course
Structure of the prokaryotic cell:
-General characteristics, microscopic study, shapes and disposal;
-Architecture of the bacterial cell genetic material, cytoplasm, cytoplasmic membrane, cell wall peptidoglycan and organization of the cell wall in Gram +, Gram- and acid-resistant capsule, pili, flagella
Reproduction of bacteria:
-Cell division, bacterial spore, VBNC.
Cultivation of bacteria:
-Nutritional requirements of microorganisms, culture media, bacterial growth, growth curve of bacteria, cultivation techniques.
-Energy and enzymes
-Energy metabolism: bacterial fermentation, aerobic and anaerobic respiration, phosphorylation, macromolecular synthesis (DNA, RNA, proteins, peptidoglycan).
-Plasmids and antibiotic resistance.
-Mutations and their chemical bases
-Genetic recombinations (transformation, translation, conjugation)
-Mechanisms of host colonization;
-Deep-tissue penetration of the host organism
-Evasion mechanisms of host defense
-Virulence factors: flagella, capsule, fimbriae, peptidoglycan, teichoic acids, outer membrane proteins, enzymes, bacterial exotoxins, lipopolysaccharide (endotoxin).
Notes on the mechanism of action of antibacterial drugs
Main characteristics of some groups of bacteria:
Staphylococci, streptococci, pneumococci, Enterobacteriaceae (Salmonella, Escherichia, Yersinie), Campylobacter, Helicobacter, Vibrio
-general characteristics and classification;
-structure of the virions (genome, capsid, pericapsid)
Replicative cycle of viruses:
-stages of the viral replication cycle (adsorption, penetration, exposure, macromolecular synthesis, assembly)
-replicative cycles of RNA and DNA viruses of medical interest.
Cultivation of viruses
Pathogenicity of the virus
Microbiological and virological diagnosis
General characteristics of fungi and protozoa of medical interest
Basics of Immunology:
-the constitutive defenses against infection (professional phagocytes, phagocytosis, complement, interferon)
-the inducible defenses against infection (the humoral immune response, the cell-mediated immune response)
Learning Achievements (Dublin Descriptors)
Knowledge and understanding ability. Knowledge of the microbial importance and role especially for the human health. Understanding the specific words and language of this discipline
Ability to apply knowledge and understanding. Understanding the microbiology importance as biological subject to study and understand the morphological, metabolic and genetic features of microorganisms
Independent judgment. Understanding the bacteria importance as simplified models to study more complex organisms
Communicative ability. Capability of using the microbiological language and of linking the different microbiological feaures.
Learning capability. Acquired knowledge will allow the student to understand the characteristics of human host-microorganism interaction.
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
Possible seminars agreed upon with students
Didactics, Attendance, Course Books and Assessment
- Course books
M. La Placa, Principi di microbiologia medica, Ed. Esculapio
M. Madigan, J. Martinko, BROK, Biologia dei Microrganismi, Ed. Ambrosiana
G. Dehò, E. galli Biologia dei microrganismi, Ed. Ambrosiana
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