The aim of the course is to provide to the students the knowledge of the functional groups of the organic molecules, studying their properties, formation and reactivity, through the study of the main mechanisms, to demonstrate the chemical reactions analyzed.

ORGANIC REACTIONS

Introduction of functional groups as a substrate for organic reactions. Classification of organic reactions: addition, elimination, substitution. Main reagents: acids and bases according to Bronsted-Lowry and Lewis; nucleophiles and electrophiles. Inductive and conjugative effects. Limit structures of resonance.

ALKENES AND ALKYNES

Nomenclature. Geometric cis and trans isomerization. Rules of CIP. Nomenclature E and Z. Physical properties and acidity. Methods of preparation. Electrophilic addition (Markovnikov reactions). Main electrophilic addition reactions. Redox reactions.

BENZENE AND ITS DERIVATIVES

Structure of benzene. Aromaticity (Huckel rule). Nomenclature. Physical properties. Electrophilic aromatic substitution and types of reactions. Activating and deactivating substituents. Rules of orientation. Reactions on arenes.

STEREOCHEMISTRY

Stereocenter. Fisher formulas and their use. R and S absolute configuration and relative d and l. Enantiomers. Diastereomers, optical rotation.

ALKYL HALIDES

Nomenclature. Preparation. Main reactions: the Grignard reagents, SN1 and SN2, E1 and E2 reactions.

ACOHOLS, PHENOLS, AND EPOXIDES

Nomenclature, physical properties, preparation, chemical properties: acidity and basicity, reactivity: nucleophilic substitution, elimination, redox, preparation of Grignard reagents.

AMINES

Nomenclature. Methods of preparation. Physical properties. Chemical properties: basicity. Principal reactions with acids, carbonyl compounds.

ALDEHYDES AND KETONES

Carbonyl group. Nomenclature. Methods of preparation. Physical properties. Nucleophilic addition reactions. Redox reactions. Reactions on the carbon in alpha position: tautomerism and aldolic condensation.

CARBOXYLIC ACIDS AND THEIR DERIVATIVES

Nomenclature. Preparation. Physical properties. Acidity. Esters: nomenclature, preparation and properties. Saponification. Fatty acids.

Nomenclature of carboxylic acid derivatives. Physical properties. Addition-elimination mechanism (SNA). Reactivity of derivatives. Acidic chlorides. Anhydrides. Amides. Esters. Claisen condensation. Polyfunctional compounds of biochemical interest. Decarboxylation.

The student will have to demonstrate its mastery of basic knowledge about the general chemistry.

The student must show knowledge and understanding of organic reactions required to produce synthetic processes of relatively complex molecules.

The student must show to apply their knowledge, understanding and skills in solving problems related to the behavior of organic substances.

The student will be able to communicate clearly with a chemical language adapted its conclusions.

The student will have developed learning skills that will enable him to continue studying in a self-directed or autonomous.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Teaching

frontal lessons

Course books

John McMurry-FONDAMENTI DI CHIMICA ORGANICA-ZANICHELLI

Assessment

oral examination

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.