The objective of the Molecular Pathology and Laboratory course is to consider the pathology from a molecular point of view. Students will acquire informations concerning the altered molecular patterns - in different models of disease (focusing the neoplastic diseases) - with particular attention to epigenetics mechanisms  . Additionally, several experimental approaches will be considered to study the most relevant biological processes (e.g. apoptosis, gene expression, epigenetic profiles, etc.)

- The control of DNA stability: repair versus mutation

-  Regulation of the gene expression: from transcription factors to  

  chromatin structure

-       Experimental approaches for gene expression studies

-       Methods for epigenetic studies

- Growth Factors Signaling and Oncogenes

- Growth inhibition and tumor suppressor genes

- Methods to study the cell cycle

-  Molecular mechanism driving apoptosis and cellular senescence

-  Experimental procedures to monitor apoptosis /senescence

-  The paradoxical model of APL: from the mechanism of the disease to therapy

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Knowledge and understanding - Acquisition of the tools to understand the molecular mechanisms of disease. Ability to use the language of their specific discipline.

Applying knowledge and understanding - Ability to recognize and apply the cognitive tools and the rigorous approach of the  Molecular Pathology as rational of any activity related directly and indirectly to health protection.

Indipendence of judgment - Being able to learn and independently evaluate the results of investigations on the pathogenesis and diagnosis of diseases

Communicative skills 
- Ability to explain, in a simple, immediate and exhaustive manner the acquired knowledge and to know how to interface with future professional roles (researchers, students, health-operative).

Learning ability - Upgrade capabilities through consultation of the scientific literatue of the discipline. Ability to participate, using the knowledge gained in the course, the continuous updating initiatives in the professional field.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Lectures will be available online on the official site "blended learning" 

Teaching

Lectures

Attendance

none

Course books

1) Lauren Pecorino - MOLECULAR BIOLOGY OF CANCER: mechanisms, targets and therapeutics. Third Edition

2) Robert A. Weinberg - THE BIOLOGY OF CANCER. Second Edition

Assessment

Oral examination

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

Lectures

Attendance

none

Course books

1) Lauren Pecorino - MOLECULAR BIOLOGY OF CANCER: mechanisms, targets and therapeutics. Third Edition

2) Robert A. Weinberg - THE BIOLOGY OF CANCER. Second Edition

Assessment

Oral examination

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

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