Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


ORGANIC CHEMISTRY II
CHIMICA ORGANICA II

Reactivity and synthesis in Organic Chemistry
Reattività e sintesi in chimica organica.

A.Y. Credits
2017/2018 10
Lecturer Email Office hours for students
Giovanni Piersanti
Teaching in foreign languages
Course partially taught in a foreign language English
This course is taught partially in Italian and partially in a foreign language. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

Assigned to the Degree Course

Industrial Pharmacy (LM-13)
Curriculum: PERCORSO COMUNE
Date Time Classroom / Location
Date Time Classroom / Location

Learning Objectives

Bring your mastery of synthetic organic chemistry right up to the current year!

This course is intended for any chemist who requires knowledge of the most recent methods in organic synthesis. The course materials also cover the strategies by which syntheses of organic compounds are designed and are continuously updated from the current literature right up to the time of each presentation of the course. The vast majority of the materials are from the 2000′s supplemented with some older references provided for the purpose of placing the most modern methods in a proper historical perspective.

Program

1. Heterocycles (1 week)
Nomenclature of heterocyclic compounds. Pyrrole, Furan, Thiophene, Indole, Benzofuran and Benzotiophene, physicochemical properties, synthesis and reactivity. Pyridine, Quinoline and Isoquinoline: physico-chemical properties, synthesis and reactivity. Diazynes: Pirimidine, Pirazine, Piridazine. physico-chemical properties, synthesis and reactivity.
2. Biological Chemistry (1 Week)
Lipids, Carbohydrates, Amino Acids, Peptides and Proteins, Nucleic Acids.
3. Chirality and Sterechemistry (1 week)
Short overview of basic concepts (Organic Chemistry I) - Enantiomers, Diastereomers, Epimers Meso Compounds and Prochirality. Atropoisomers -
Prochirality - Stereospecific and stereoselective reactions.
4. Modern Organic Reactions (8 weeks)
Oxidation, Reduction, Redox Neutral reactions, Cerbenes and Nitrenes, Advanced functional group tranformations, Peryciclic reactions, Organometallics, Protecting groups
5. Synthesis and Key Concepts in Stereoselective Synthesis (1 weeks)

Bridging Courses

General, physic and organic chemistry fundamentals.

Learning Achievements (Dublin Descriptors)

D1 - KNOWLEDGE AND UNDERSTANDING
At the end of this activity, students should be able to:
1) thoroughly know the structure-property relationships of the main families of organic compounds;
2) familiar with the principles that drive the organic reactions and allow the rational interpretation of reaction mechanism;
3) know the chemical-physical properties of polyfunctional organic molecules to become familiar with the compounds often used in laboratory;
4) learn about the centrality of organic chemistry at the interface with biochemistry and pharmaceutical chemistry;
5) know the main databases of chemical interest and the higher organic chemistry electronic journals.

D2 - APPLYING KNOWLEDGE AND UNDERSTANDING
At the end of this activity, students should be able to:
1) describe reaction mechanisms in multifunctional organic molecules;
2) classify organic transformations on the basis of the interactions between the different functional groups present in an organic molecule;
3) describe the design of organic transformations necessary to prepare simple organic compounds;
4) describe the most functional recognition reactions of the main functional groups;
5) describe the qualitative and quantitative aspects that allow to correctly predict the experimental results.

D3 - MAKING JUDGEMENTS
At the end of this activity, students should be able to:
1) acquire the basic principles of organic synthesis for the development of simple synthetic sequences of polyfunctional organic compounds;
2) ability to apply the acquired knowledge and understanding of reaction mechanisms to solve organic chemistry problems;
3) propose modern synthetic strategies with particular attention to the protection-deprotection of functional groups;
4) comparing the spettroscopic data to determine the structures of unknown organic compounds;
5) ability to work in groups and to draw up a lab report.

D4 - COMMUNICATION SKILLS
After completing the courser, students will have to prove that they are able to clearly describe the use of various concepts learning during lessons.

D5 - LEARNING SKILLS
At the end of the activity, students should be able to find and apply new information, than those provided in the training activity, to evaluate and compare.

Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Supporting Activities

Lessons and exercise. Practical examples.


Teaching, Attendance, Course Books and Assessment

Teaching

Frontal lesson e and youTube. https://www.youtube.com/user/pierorganic1

Attendance

The attendance is NOT mandatory but strongly reccomended.

Course books

Organic Chemistry- Clayden, Greeves, Warren, Wothers - Second Edition, Ed. OXFORD
Modern Organic Synthesis- An Introduction Zweifel, NantzW.H. Freeman and Company
Strategic Applications of Named Reactions in Organic Synthesis - Laszlo Kurti, Barbara Czako. Elsevier

Assessment

The final evaluation entail written and oral examination (optional)

There are ongoing evaluations

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.

Additional Information for Non-Attending Students

Teaching

Frontal lesson e and youTube. https://www.youtube.com/user/pierorganic1

Materials: http://www.people.uniurb.it/GiovanniPiersanti/organica2/index.html

Attendance

The attendance is NOT mandatory but strongly reccomended.

Course books

Organic Chemistry- Clayden, Greeves, Warren, Wothers - Second Edition, Ed. OXFORD

Assessment

The final evaluation entail written and oral examination (optional)

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.

Notes

It is strongly reccommended to attend the class.

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