Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


PHARMACOLOGY AND PHARMACOGNOSY
FARMACOLOGIA E FARMACOGNOSIA

A.Y. Credits
2020/2021 6
Lecturer Email Office hours for students
Andrea Guidarelli Any working day (it is advisable to make an appointment by email at the address given, or by telephone at +39 0722 303524)
Teaching in foreign languages
Course with optional materials in a foreign language English Spanish
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

Assigned to the Degree Course

Pharmaceutical Chemistry and Technology (LM-13)
Curriculum: PERCORSO COMUNE
Date Time Classroom / Location
Date Time Classroom / Location

Learning Objectives

The aim of the course is to provide knowledge about routes of administration, metabolism, distribution, and elimination of synthetic and plant-derived drugs as well as the basic concepts of their therapeutic and adverse effects. In the part of the course related to pharmacognosy, attention will be devoted to the description of the most important medicinal plants and to preparation of drugs of natural origin. In particular, this part of the course will provide knowledge on the production of plant extracts, their chemical composition and biological activity of individual compounds. Their pharmacological and nutraceutical use in pharmacy, industry and research will be discussed.

Program

PHARMACOLOGY: general principles: drug, medicine and poison.
Pharmacokinetics: Physicochemical factors in transfer of drugs across membranes. Drug absorption, bioavailability, and routes of administration. Distribution of drugs. Biotransformation of drugs. Excretion of drugs. Clinical pharmacokinetics.
Pharmacodynamics: Mechanisms of drug action. Drug receptors. Receptors for physiological regulatory molecules. Quantitation of drug-receptor interactions. Dose-effect relationship.
PHARMACOGNOSY: Definition and aim of pharmacognosy. Definition and classification of plant drugs. Factors affecting the activity of plant drugs: natural, endogenous, exogenous and preparation-dependent. Plant drugs: preservation, analysis, identification, quality control, distinctive characters, endogenous active substances, therapeutic strategies, toxic effects.
Natural products and herbal drugs used in pharmacy and medicine
Carbohydrates: (monosaccharides, oligosaccharides, polysaccharides, polysaccharides from (algae, gum, mucilages).
lipids: (oils, fatty acids, cere).
Phenilpropanes: (cumarines, lignans, flavonoids, tannins)
Glycosides: (anthraquinones, cyanogenic, saponins, alcoholic, phenolic
Alkaloids: (phenylalkylamines, isoquinolines, indoles, quinolines, piridines, piperidines, tropanes, purines). Anticancer drugs derived from plants.

Bridging Courses

The student must have successfully passed the following exams: Biochemistry, Molecular Biology and Pharmaceutical Botany with elements of Phytochemistry.

Learning Achievements (Dublin Descriptors)

Learning outcomes will be: a)  basic knowledge about drug metabolism (administration, clearance, therapeutics, adverse effects); b) identification, structure and reactivity of biologically active substances, including  therapeutic and  toxic effects of the most important plant and animal drugs.

At the end of the course, students should have acquired basic knowledge for the correct use of synthetic drugs as well as drugs derived form medicinal plants.

Knowledge and understanding. At the end of the course, the student will have the skills to understand of the concepts of pharmacokinetics and pharmacodynamics and the notions relating to the molecular mechanisms underlying the action of synthetic or natural drugs.

Ability to apply knowledge and understanding. At the end of the course, the student must be able to understand how the therapeutic response of drugs is conditioned by their pharmacokinetics and pharmacodynamics characteristics

Judgment. At the end of the course, the student must be able to analyse and then predict therapeutic alternatives based on the pharmacokinetics pharmacodynamics parameters of the different drugs (natural or synthetic).

Communication skills. At the end of the course, the student must demonstrate that he/she is able to expose the notions referred in section knowledge and understanding through a scientific and critical lexicon.

Learning skills. At the end of the course, the student must demonstrate that he is able to independently know and learn the pharmacokinetics and pharmacodynamics of synthetic and natural drugs that modulate the different pharmacological responses. Furthermore, will be able to build up his scientific knowledge in a critical way, using not only the study material provided by the professor but also dedicating himself to in-depth studies.

Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Supporting Activities

Frontal lessons (MS Power Point).

The teaching material prepared by the lecturer (such as for instance slides, lecture notes, exercises) and specific communications from the lecturer can be found, together with other supporting activities, inside the Moodle platform › blended.uniurb.it


Didactics, Attendance, Course Books and Assessment

Didactics

Frontal lessons (MS Power Point).

Course books

H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G. Henderson. "Farmacologia". 8th Edition
F. Clementi, G. Fumagalli, "Farmacologia Generale e Molecolare". 4th Edition.
F. Capasso. "Farmacognosia" 2th Edition. SPRINGER, 2012.

Assessment

The course is examined through oral examination with questions to evaluate the students' knowledge about the mechanisms of basic principles of pharmacology and pharmacognosy;  address the issues related to potential interactions between of synthetic drugs as well as drugs derived form medicinal plants, dietary supplements and food. The final mark (out of 30) will be based on the skill of the students to answer properly to the questions.

Additional Information for Non-Attending Students

Didactics

Frontal lessons (MS Power Point).

Course books

H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, G. Henderson. "Farmacologia". 8th Edition
F. Clementi, G. Fumagalli, "Farmacologia Generale e Molecolare". 4th Edition.
F. Capasso. "Farmacognosia" 2th Edition. SPRINGER, 2012.

Notes

It is highly recommended to previously to have or passed the exam of General Physiology.

« back Last update: 08/06/2021

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