Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


CELL BIOLOGY AND GENETIC
BIOLOGIA CELLULARE E GENETICA

A.Y. Credits
2020/2021 8
Lecturer Email Office hours for students
Francesca Andreoni
Teaching in foreign languages
Course with optional materials in a foreign language English
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

Assigned to the Degree Course

Biotechnology (L-02)
Curriculum: PERCORSO COMUNE
Date Time Classroom / Location
Date Time Classroom / Location

Learning Objectives

The course aims to give students the knowledge about cell organization at morphological and molecular level. The course also highlights the major themes and experiments of classical and modern genetics.

Program

CELL BIOLOGY
General principles of living matter organization
- Prokaryotic cell and eukaryotic cell
Virus, viroid and prions.
Chemistry of life
- Inorganic components, water and mineral.
- Biological macromolecules: carbohydrates, lipids, proteins, nucleic acids.
Gene expression
- RNA transcription and RNA processing.
- translation and the genetic code.
Cell membrane
- Structure and function.
- Membrane transit.
Endomembrane system
- Endoplasmic reticulum, ribosomes, Golgi apparatus, lysosomes. Vacuolar compartmentation: exocytosis and endocytosis.
Peroxisomes
Cell nucleus
- Nuclear envelope, Nucleoplasm and nucleoskeleton, Nucleolus.
 -Organization of chromatin: euchromatin and heterochromatin. Chromosomes..
Mitochondria and energy metabolism.
Cytoskeleton
- Microfilaments, intermediate filaments, microtubules.
- Cilia and flagella.
Cell cycle
- DNA replication
- Mitosis.
- Cell cycle regulation
- Meiosis.
Cells in their social context
- Tissues
- Cell differentiation.
- Development of multicellular organisms

GENETICS
Structure and function of nucleic acids
- The DNA. Genes: Genotype and Phenotype.
- The chromosomes and cell reproduction.
Mendelian inheritance
- Mendel's laws.
- Homozygote and heterozygote.
- Autosomal recessive and dominant inheritance; family tree.
Chromosomal basis of inheritance
- Kariotype, autosomal and sex chromosomes
- The chromosome theory of heredity.
- Sex determination and sex-linked genes.
- Dosage compensation of X-linked genes
- Y-linked genes.
Extensions and deviations of Mendelian inheritance
- Incomplete dominance; polyallelic inheritance; co-dominance.
- Essential genes and lethality
- Penetrance and expressivity.
- Interactions between genes and the environment.
- Gene interaction and epistasis
Mutation
- The molecular basis of mutation.
- DNA repair mechanisms.
Variation in chromosome number and structure
- Polyploidy; aneuploidy.
- Rearrangements of chromosome structure.
- Cytogenetic techniques.
Association and genetic recombination.
Non Mendelian inheritance

- Mitochondrial inheritance.
- Genomic imprinting.
 

Learning Achievements (Dublin Descriptors)

Knowledge and understanding
The student should demonstrate possession of basic knowledge about essential components of cell, sugars, proteins, lipids and nucleic acids; the student should also demonstrate understanding about organization and function of cell and principles of classical and modern genetics.
Applying knowledge and understanding
The student must show applying knowledge and understanding to reason out, showing the ability to discuss and connect topics as well as analyze experiments of biology and solve problems of genetics.
Making judgements
The student should demonstrate to critically examine the acquired knowledge and independently discuss questions and applied problems.
Communication skills
The student must show possession of communication skills with colleagues and superiors using the appropriate terminology.
Learning skills
The student must show possession of learning skills to update knowledge about this discipline.

Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Didactics, Attendance, Course Books and Assessment

Didactics

Lessons

Course books

G. Plopper - Principi di Biologia della cellula - I edizione ZANICHELLI
J. Hardin, G.P. Bertoni, L.J. Kleinsmith - Becher: Il mondo della cellula - VIII edizione PEARSON
B. A. Pierce - GENETICA - II edizione ZANICHELLI
P.J Russel - GENETICA: un approccio molecolare - IV edizione PEARSON.

Assessment

Oral examination with questions about both the cellular biology and genetics, evaluating the ability to make connections between the subjets of study. 

Additional Information for Non-Attending Students

Didactics

Lessons 

Course books

G. Plopper - Principi di Biologia della cellula - I edizione ZANICHELLI
J. Hardin, G.P. Bertoni, L.J. Kleinsmith - Becher: Il mondo della cellula - VIII edizione PEARSON
B. A. Pierce - GENETICA - II edizione ZANICHELLI
P.J Russel - GENETICA: un approccio molecolare - IV edizione PEARSON.

Assessment

Oral examination with questions about both the cellular biology and genetics, evaluating the ability to make connections between the subjets of study. 

« back Last update: 05/10/2020

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