The course will provide the molecular basis of diseases that most frequently affect the adult population of the industrialized societies . It will also  provide  guidance regarding prevention of such diseases through appropriate physical activity and healthy nutrition.

The course will address the following topics in the order below. 

Mechanisms of cellular damage. Cell death: apoptosis and necrosis.

Innate immunity: cells, receptors and mechanisms of action.

Inflammation

Acquired immunity: lymphocytes and cellular basis of adaptive immunity, B cells and antibodies, T cells and MHC proteins.

Relations between metabolic organs in various nutritional and hormonal  states .

Diabetes mellitus:  diabetes type 1 and 2; Insulin: structure, function and mechanism of action; molecular mechanisms of insulin resistance.

Obesity: white and brown adipose tissue; biochemical composition of adipocyte; Termogenesis, Adipose tissue as secretory organ.

Synthesis, structure and function of LDL and HDL.

Atherosclerosis as chronic inflammatory response

Molecular bases of metabolic syndrome

Cancer: Molecular basis of the behavior of neoplastic cells. Oncoprotective role of physical exercise

Anti-inflammatory role of physical exercise and diet

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Knowledge and understanding. The student must demonstrate that the basic knowledge regarding the defense mechanisms adopted by the human organism in response to various harmful stimuli are acquired. The student must demonstrate to have understood the molecular mechanisms underlying the establishment of metabolic diseases such as obesity, type 2 diabetes, metabolic syndrome and atherosclerosis, as well as tumors.

Applied knowledge and understanding. The student must demonstrate an understanding of the concepts and  the ability to transfer the acquired concepts into the practical activity 

Making judgements. The student must demonstrate the ability to use knowledge and concepts in the planning of personalized programs of functional re-education considering the characteristics and clinical condition of the patient.

Communication skills. The student must show the possession of the communication skills, using the correct terminology and must be able to interface with other professional figures operating in the health sector

Learning skills. The student must be able to build his path of scientific growth in a critical and autonomous way, being able to correctly use the study material recommended by the teacher as well as the in-depth material that he can procure himself. These skills will be stimulated by the teacher who will propose insights on topics of interest

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

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Teaching

front lessons

Attendance

no

Course books

Patologia generale e fisiopatologia generale   Pontieri , Russo, Frati V Ed. Piccin Nuova Libraria  2015  Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15),  diabetes (Chapter 54), obesity (Chapter 55), lipoprotein metabolism and atherosclerosis (Chapter 46 and  Chapter 57)  

Immunologia  Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation . 

Other additional material will be available in the platform Moodle 

Assessment

The assessment of learning includes an oral exam in which the student will have to answer 3 open questions. The evaluation will be formulated according to the following criteria:

less than 18: skill level not enough 

18-20: skill level enough 

21-23: skill level satisfactory

24-26: skill level good

27-29: skill level very good •

30-30 with honors: skill level excellent

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

The same of attending students

Course books

Patologia generale e fisiopatologia generale   Pontieri , Russo, Frati V Ed. Piccin Nuova Libraria  2015  Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15),  diabetes (Chapter 54), obesity (Chapter 55), lipoprotein metabolism and atherosclerosis (Chapter 46 and  Chapter 57)  

Immunologia  Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation . 

Other additional material will be available in the platform Moodle 

Assessment

The assessment of learning includes an oral exam in which the student will have to answer 3 open questions. The evaluation will be formulated according to the following criteria:

less than 18: skill level not enough 

18-20: skill level enough 

21-23: skill level satisfactory

24-26: skill level good

27-29: skill level very good •

30-30 with honors: skill level excellent

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.