The course aims to provide students with the basic knowledge of human disease and to provide an overview of modern cellular and molecular immunology seeking to understand the mechanisms that regulate the normal, but also the "abnormal", functioning of immune system. It will be taken into account also the techniques used for the study and diagnosis of disease patterns examined.

1. Cellular injury
1.1. Cellular injury
1.1 Molecular mechanisms of cancer
1.2 Reversible injury vs irreversible injury
1.3 Free radicals and chemical injury
1.4 Ischemia and reperfusion injury
2. Cellular adaptation
2.1 Atrophy, ipertrophy, hyperplasia e metaplasia
3. Cell death
3.1 Apoptosis
3.2 Necrosis
4. Inflammation
4.1 Acute inflammation: mechanism, phagocytosis and degranulation
4.2 Chemical mediators of inflammation
4.3 Chronic inflammation: mechanism
4.4 Repair processes
4.5 Granulomatous inflammation
5. Neoplastic diseases
5.1 Definition, classification and general features
5.2 Differentation and anaplasia
5.3 Tumour progression
5.4 Environmental factors
5.5 Genetic lesions of cancer: proto-oncogenes, oncosuppressors and oncogenes
5.6 Cell cycle regulation and cancer
5.7 Acute Promyelocytic Leukaemia - APL
6. Immune system
6.1 General features
6.2 Immunity: natural vs acquierd
6.3 Immunity: active vs passive
6.4 Humoral theory and cellular theory of the immune response
6.5 Cells of the immune system
6.6 Toll-like receptors (from Drosophila to human)
6.7 Major histocompatibility complex (MHC)
6.8 T cell receptor (TCR)
6.9 Immunological tolerance
7. Hypersensitivity diseases (or reactions)

none

Knowledge and understanding - Acquisition of the tools to understand the mechanisms of disease. Ability to use the language of their specific discipline.

Applying knowledge and understanding - Ability to recognize and apply the cognitive tools and the rigorous approach of the Pathology as rational of any activity related directly and indirectly to health protection.

Indipendence of judgment - Being able to learn and independently evaluate the results of investigations on the pathogenesis and diagnosis of diseases

Communicative skills ?- Ability to explain, in a simple, immediate and exhaustive manner the acquired knowledge and to know how to interface with future professional roles (researchers, students, health-operative).

Learning ability - Upgrade capabilities through consultation of the scientific literatue of the discipline. Ability to participate, using the knowledge gained in the course, the continuous updating initiatives in the professional field.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Supporting activities are not planned

Teaching

Lectures

Attendance

It is recommended to attend classes

Course books

- Pontieri, Russo, Frati - Patologia Generale - PICCIN

- Rubin, Strayer - Patlogia Generale e Anatomia Patologica - PICCIN
- Robbins e Cotran - Le basi patologiche delle malattie - ELSEVIER
- Abbas- Le basi dell'Immunologia - MASSON -

Assessment

oral examination

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Course books

- Pontieri, Russo, Frati - Patologia Generale - PICCIN

- Rubin, Strayer - Patlogia Generale e Anatomia Patologica - PICCIN
- Robbins e Cotran - Le basi patologiche delle malattie - ELSEVIER 
- Abbas- Le basi dell'Immunologia - MASSON -

Assessment

Oral examination

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.