The course aims to provide theoretical and practical competence in the qualitative analysis of organic substances of pharmaceutical interest, registered and not registered in the Official Pharmacopoeia (F.U.) through systematic analysis of organic functional groups and through knowledge of the theoretical principles and applications of instrumental analytical methods.

- State of aggregation of matter and chemical-physical characteristics

- Solubility, dissolution process, types of solvents, structure-solubility relationships, solubility tests, pKa, solubility in aqueous environment at varying pH

- Determination of some chemical-physical constants: melting point, boiling point, melting point in mixture

- Qualitative elemental analysis (C, H, N, S, P, X)

- Recognition analysis of metal salts of organic acids

- General tests and structural analysis through the chemical properties of functional groups and derivatives

- Recognition and purity tests of the main pharmaceutical structures according to the monographs of the F.U. and E.P.

- Recognition and purity tests of the main pharmaceutical structures according to the monographs of the F.U. and E.P.

- Scheme for the systematic identification of an unknown organic substance

- Structural determination of organic substances: elemental analysis, IR spectrophotometry, UV-VIS, polarimetry, Mass spectrometry and NMR

To be able to access the laboratory attendance it is necessary to have passed the Organic Chemistry I exam and to have obtained the attendance of the Quantitative Pharmaceutical Analysis laboratory with laboratory.

D1- KNOWLEDGE AND UNDERSTANDING- Learning of traditional qualitative techniques in organic/inorganic chemistry; ability to understand the most recent instrumental techniques of organic qualitative analysis applied to substances belonging to the Official Pharmacopoeia. These skills will be assessed through practical, written and oral tests.
D2- ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING- Ability to apply instrumental and non-instrumental qualitative analytical techniques for the analysis of unknown compounds belonging to the Official Pharmacopoeia. These skills will be assessed through practical, written and oral tests.
D3- JUDGEMENT ABILITY- Acquisition of the ability to make judgments to undertake analyses of unknown substances (F.U.) autonomously and independently. These skills will be assessed through targeted application questions.
D4- COMMUNICATION SKILLS- Development of communication skills suitable for the presentation of data collected during the analyses of unknown substances. Ability to report the results in an analytical and synthetic way. Ability to describe the principles and concepts learned during the course through appropriate language and with appropriate examples. These skills will be assessed both during the unknown practical test carried out during the course and through the oral interview.
D5-LEARNING ABILITY- The student, at the end of the course, must have developed good autonomy both for carrying out qualitative analyses of unknown organic/inorganic substances and for updating their knowledge through the study of literature, databases, etc.. These skills, as far as possible, will be stimulated by the teacher both during the unknown practical test carried out during the course and through the written and oral exam.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

No support activities are planned.

Teaching

theoretical lectures and individual laboratory exercises

Attendance

Attendance at lectures is not mandatory but strongly recommended. Attendance at laboratory lessons is mandatory. In order to access laboratory attendance, it is necessary to have passed the Organic Chemistry I exam and to have obtained attendance at the Quantitative Pharmaceutical Analysis laboratory with laboratory.

Course books

-A. Carta, M. G. Mamolo, F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa (Analisi qualitativa organica ed inorganica non strumentale), EdiSES Ed.
- D. G. Watson, Analisi Farmaceutica EdiSES Ed. 
- Farmacopea Ufficiale Italiana X Ed.

Assessment

Subject to approval of the practical laboratory part, the assessment of learning includes a written and an oral test aimed at verifying the student's acquisition of the theoretical concepts presented in class and the practical procedures used during the laboratory exercises. The student will be required to have knowledge regarding the solubility and recognition/determination of the main functional groups in substances of pharmaceutical interest with particular attention also to the instrumental and separation techniques described in the theoretical lessons. The student's ability to connect the topics covered during the lessons as well as to solve practical and applicative problems will also be verified. The written/oral test is judged with a grade in thirtieths.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

No recovery activities are planned.

Attendance

Attendance at lectures is not mandatory but strongly recommended. Attendance at laboratory lessons is mandatory. In order to access laboratory attendance, it is necessary to have passed the Organic Chemistry I exam and to have obtained attendance at the Quantitative Pharmaceutical Analysis laboratory with laboratory.

Course books

-A. Carta, M. G. Mamolo, F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa (Analisi qualitativa organica ed inorganica non strumentale), EdiSES Ed.
- D. G. Watson, Analisi Farmaceutica EdiSES Ed. 
- Farmacopea Ufficiale Italiana X Ed.

Assessment

Subject to approval of the practical laboratory part, the assessment of learning includes a written and an oral test aimed at verifying the student's acquisition of the theoretical concepts presented in class and the practical procedures used during the laboratory exercises. The student will be required to have knowledge regarding the solubility and recognition/determination of the main functional groups in substances of pharmaceutical interest with particular attention also to the instrumental and separation techniques described in the theoretical lessons. The student's ability to connect the topics covered during the lessons as well as to solve practical and applicative problems will also be verified. The written/oral test is judged with a grade in thirtieths.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.