The course aims at learning the principles of genetics, nutrition and personalized genomic medicine.

1. Basic principles of genetics

1.1 Chromosomes (chromatin, euchromatin and heterochromatin, mitosis and meiosis, gametogenesis and fertilization, chromosomal sex determination, human karyotyping, banding techniques, chromosomal pathology)

1.2 Study of genealogy trees

1.3 Principles of heredity: Autosomal inheritance (Dominant autosomal characters and Recessive autosomal characters), Sex related inheritance, Dynamic mutations

1.4 Multifactorial inheritance (genetic susceptibility, normal variation, susceptibility alleles and protective alleles, multifactorial diseases)

2. Genetic bases of drug response

2.1 Drug Metabolism

2.2 Undesirable effects

2.3 Individual response and genetic determinants

2.4 Personalized Medicine

3. Nutrigenomics

3.1 Food metabolism

3.2 Metabolism genes: cytochromes and metabolizers

3.3 Interaction between bioactive food and genome

3.4 Metabolic diseases (metabolic syndrome, diabetes, celiac disease, obesity)

3.4 Multifactorial diseases and eating habits: cancer

3.5 Genetic counselling

4. Individual response

4.1 nutrient-pharmacogenomic molecular pathways

4.2 Lifestyle: circadian biorhythms and individual response

5. Epigenetics and nutri-epigenenetics

The student will show mastery in basic knowledge of molecular genetics, cytogenetics, familial pedigrees, patterns of disease transmission, pharmacogenomics, nutrigenomics and personalized medicine.

The student will demonstrate understanding of concepts and theories provided by the course; students will provide examples of genetic diseases (biological, metabolic, clinical, hereditary, and analytical skills); they will be able to analyse familial pedigrees, identifying patterns of transmission, recurrence risks, available tests.

The student will show the ability to use knowledge and concepts that allow to apply logic of the discipline. In particular, students have to be able to identify appropriate personalized medicine strategies in order to administer metabolic tests; they will simulate the design of diagnostic pathways; they will be able to propose possible solutions to problematic cases.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Supplementary teaching activities and exercise

Teaching

The course includes frontal lessons, exercises and research programmes

Course books

GENETICA MEDICA PRATICA - Giuseppe Novelli - Emiliano Giardina - ARACNE EDITRICE

Assessment

Oral exam

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.