Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


ORGANIC LABORATORY TECHNIQUES FOR THE SYNTHESIS AND EXTRACTION OF DRUGS
LABORATORIO DI PREPARAZIONE ESTRATTIVA E SINTESI DEI FARMACI

A.Y. Credits
2021/2022 9
Lecturer Email Office hours for students
Gilberto Spadoni Monday through Friday, on appointment via e-mail: gilberto.spadoni@uniurb.it
Teaching in foreign languages
Course with optional materials in a foreign language English
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

Assigned to the Degree Course

Industrial Pharmacy (LM-13)
Curriculum: PERCORSO COMUNE
Date Time Classroom / Location
Date Time Classroom / Location

Learning Objectives

The aim of the course is to provide to the students with theoretical-practical knowledge to the design and synthesis of pharmacologically active molecules, and the modern approaches used for their isolation from natural sources

Program

Organic Chemistry Laboratory safety guidelines. Planning a synthetic experiment and guidance for Writing Lab Reports including procedures and results. Experimental parameters influencing the reaction progress. Equipment and reaction processes. General purpose systems with interchangeable frosted glass joints in organic synthesis Stirring, heating and cooling of reaction mixtures. Phase transfer catalysis reactions. Equipment for special reaction techniques (catalytic hydrogenation, pressured reactions, inert atmosphere reactions).

Isolation and Purification Techniques. Filtration, Recrystallization, Sublimation, Freeze-drying, Solvent Extraction, Supercritic fluid extraction, microwave extraction, ultrasound extraction, accelerated solvent extraction and Naviglio extractor. Liquid and Organic solution Drying, Distillation, Chromatography. Determination of physical constants. Microwave application in organic synthesis.

The course will include practical laboratory experiences related to the synthesis (or isolation from natural sources) of organic substances of pharmaceutical interest. Spectroscopic data (IR, NMR, Mass) will be used to characterize the synthetized compounds.

Bridging Courses

In order to attend the laboratory practice and acquire the frequency signature, it is necessary to have passed the exam of Organic Chemistry I and attended the laboratory practice of Drug Analysis II.

In order to take the exam it is necessary to acquire the signature of attendance and have passed the examinations of Organic Chemistry I, Drug Analysis I and Drug Analysis II

Learning Achievements (Dublin Descriptors)

1. Knowledge and undertanding: Knowledge of modern extraction and synthetic methodologies applied to the synthesis/isolation of pharmacologically active molecules.

2. Ability to apply knowledge and underastanding: Ability to suitably design a synthetic procedure, identifying the critical issues and proposing methods for their resolution. The student will also be able to isolate and purify the substances of interest from the reaction mixture or from plant matrices.

3. Communication skills: Upon completion of this educational activity, the student will be able to correctly write a synthetic report The student will also be able to discuss and argue the topics covered during the course by using proper scientific terms.

4. Making judgments: At the end of the course, the student must be able to correctly design the synthetic procedure for the desired compound, starting literature information, and to use the suitable equipement.

5. Learning skills: At the end of the course the student will be able to independently find and learn new scientific information sources relating to the synthesis and isolation of organic compounds. The student will also acquire the ability to synthesize and link the diferent topics discussed with the related disciplines.

Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Teaching, Attendance, Course Books and Assessment

Teaching

Frontal oral lessons (4 cfu) and practical laboratory experiences (5 cfu)

Attendance

The frequency of laboratory experiences is mandatory.

Course books

Reference book: Vogel's Textbook of practical organic chemistry. Longman Scientific and Techical.

Assessment

The methods of assessment of learning outcomes are based on an ongoing evaluation and an oral examination. The ongoing evaluation during the performance of practical laboratory experiences, takes into account the progress that will be made by the student in terms of understanding the proposed experiences, skills and autonomy in their realization The oral exam consists of a discussion lasting about 30-40 minutes aimed at ascertaining the level of knowledge and understanding achieved by students on the theoretical/practical contents listed in the program. Questions are asked about the synthetic strategies used to prepare the proposed compounds and about the principal tecniques used for their isolation/purification. In addition, it will be evaluated the ability to speak with propriety of language and organization of the subject exposed.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Additional Information for Non-Attending Students

Attendance

The laboratory attendance is mandatory

Course books

Reference book: Vogel's Textbook of practical organic chemistry. Longman Scientific and Techical.

Assessment

The methods of assessment of learning outcomes are based on an ongoing evaluation and an oral examination. The ongoing evaluation during the performance of practical laboratory experiences, takes into account the progress that will be made by the student in terms of understanding the proposed experiences, skills and autonomy in their realization The oral exam consists of a discussion lasting about 30-40 minutes aimed at ascertaining the level of knowledge and understanding achieved by students on the theoretical/practical contents listed in the program. Questions are asked about the synthetic strategies used to prepare the proposed compounds and about the principal tecniques used for their isolation/purification. In addition, it will be evaluated the ability to speak with propriety of language and organization of the subject exposed.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

« back Last update: 05/10/2021

Il tuo feedback è importante

Raccontaci la tua esperienza e aiutaci a migliorare questa pagina.

Il tuo 5x1000 per sostenere le attività di ricerca

L'Università di Urbino destina tutte le risorse che deriveranno da questa iniziativa alla ricerca scientifica ed al sostegno di giovani ricercatori.

15 22

Se sei vittima di violenza o stalking chiama il 1522, scarica l'app o chatta su www.1522.eu

Il numero, gratuito è attivo 24 h su 24, accoglie con operatrici specializzate le richieste di aiuto e sostegno delle vittime di violenza e stalking.

Posta elettronica certificata

amministrazione@uniurb.legalmail.it

Social

Università degli Studi di Urbino Carlo Bo
Via Aurelio Saffi, 2 – 61029 Urbino PU – IT
Partita IVA 00448830414 – Codice Fiscale 82002850418
2024 © Tutti i diritti sono riservati

Top