The aim of the course is to provide to the students with theoretical-practical knowledge to the design and synthesis of pharmacologically active molecules, and the modern approaches used for their isolation from natural sources

Organic Chemistry Laboratory safety guidelines. Planning a synthetic experiment and guidance for Writing Lab Reports including procedures and results. Experimental parameters influencing the reaction progress. Equipment and reaction processes. General purpose systems with interchangeable frosted glass joints in organic synthesis Stirring, heating and cooling of reaction mixtures. Phase transfer catalysis reactions. Equipment for special reaction techniques (catalytic hydrogenation, pressured reactions, inert atmosphere reactions).

Isolation and Purification Techniques. Filtration, Recrystallization, Sublimation, Freeze-drying, Solvent Extraction, Supercritic fluid extraction, microwave extraction, ultrasound extraction, accelerated solvent extraction and Naviglio extractor. Liquid and Organic solution Drying, Distillation, Chromatography. Determination of physical constants. Microwave application in organic synthesis.

The course will include practical laboratory experiences related to the synthesis (or isolation from natural sources) of organic substances of pharmaceutical interest. Spectroscopic data (IR, NMR, Mass) will be used to characterize the synthetized compounds.

In order to attend the laboratory practice and acquire the frequency signature, it is necessary to have passed the exam of Organic Chemistry I and attended the laboratory practice of Drug Analysis II.

In order to take the exam it is necessary to acquire the signature of attendance and have passed the examinations of Organic Chemistry I, Drug Analysis I and Drug Analysis II

1. Knowledge and undertanding: Knowledge of modern extraction and synthetic methodologies applied to the synthesis/isolation of pharmacologically active molecules.

2. Ability to apply knowledge and underastanding: Ability to suitably design a synthetic procedure, identifying the critical issues and proposing methods for their resolution. The student will also be able to isolate and purify the substances of interest from the reaction mixture or from plant matrices.

3. Communication skills: Upon completion of this educational activity, the student will be able to correctly write a synthetic report The student will also be able to discuss and argue the topics covered during the course by using proper scientific terms.

4. Making judgments: At the end of the course, the student must be able to correctly design the synthetic procedure for the desired compound, starting literature information, and to use the suitable equipement.

5. Learning skills: At the end of the course the student will be able to independently find and learn new scientific information sources relating to the synthesis and isolation of organic compounds. The student will also acquire the ability to synthesize and link the diferent topics discussed with the related disciplines.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Teaching

Frontal oral lessons (4 cfu) and practical laboratory experiences (5 cfu)

Attendance

The frequency of laboratory experiences is mandatory.

Course books

Reference book: Vogel's Textbook of practical organic chemistry. Longman Scientific and Techical.

Assessment

The methods of assessment of learning outcomes are based on an ongoing evaluation and an oral examination. The ongoing evaluation during the performance of practical laboratory experiences, takes into account the progress that will be made by the student in terms of understanding the proposed experiences, skills and autonomy in their realization The oral exam consists of a discussion lasting about 30-40 minutes aimed at ascertaining the level of knowledge and understanding achieved by students on the theoretical/practical contents listed in the program. Questions are asked about the synthetic strategies used to prepare the proposed compounds and about the principal tecniques used for their isolation/purification. In addition, it will be evaluated the ability to speak with propriety of language and organization of the subject exposed.

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.

Attendance

The laboratory attendance is mandatory

Course books

Reference book: Vogel's Textbook of practical organic chemistry. Longman Scientific and Techical.

Assessment

The methods of assessment of learning outcomes are based on an ongoing evaluation and an oral examination. The ongoing evaluation during the performance of practical laboratory experiences, takes into account the progress that will be made by the student in terms of understanding the proposed experiences, skills and autonomy in their realization The oral exam consists of a discussion lasting about 30-40 minutes aimed at ascertaining the level of knowledge and understanding achieved by students on the theoretical/practical contents listed in the program. Questions are asked about the synthetic strategies used to prepare the proposed compounds and about the principal tecniques used for their isolation/purification. In addition, it will be evaluated the ability to speak with propriety of language and organization of the subject exposed.

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.