The course will focus on known molecular aspects at the basis of some neoplastic diseases. The two meetings will be characterized by a common thread represented by the concepts of "correlation" and "causality", often confused and considered synonymous. Through the experience of the speaker there will be proposed examples of human diseases, understood from a molecular point of view, as examples of misinterpretation of causality between two phenomena. The objective is therefore to make understand how experimental data can be scientifically interpreted in the search for a causal pathogenetic mechanism. The course also aims to contribute to a study approach not "driven" by what is expected but inspired by a critical evaluation of the experimental data obtained.

- The APL paradox

- Epigenetic perturbations in Human Cancers

- Aging and Histone Code: the hope of a reversible phenomenon

- c-MYC dowregulation as possible therapeutic strategy for AML: "I am going back to the start"

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D1 - Conoscenza e capacità di comprensione - Acquisizione degli strumenti per la comprensione dei meccanismi epigenetici ed il loro ruolo nel regolare l'espressione genica. Capacità di utilizzare il linguaggio specifico proprio di questa disciplina.

D2 - Capacità di applicare conoscenza e comprensione - Capacità di riconoscere ed applicare gli strumenti conoscitivi ed il rigore metodologico dell' Epigenetica per il razionale esercizio di qualsiasi attività connessa direttamente ed indirettamente alla tutela della salute.

D3 - Autonomia di giudizio - Essere in grado di sapere valutare in maniera autonoma i risultati di studi volti a chiarire i meccanismi epigenetici in relazione sia allo stato fisiologico che patologico.

D4 - Abilità communicative - Capacità di spiegare, in maniera semplice, immediata ed esaustiva le conoscenze acquisite nonché di sapersi interfacciare con la realtà professionale future (ricercatori, studenti, operatori sanitari).

D5 - Capacità d’apprendimento - Capacità di aggiornamento tramite la consultazione delle pubblicazioni scientifiche proprie della disciplina in oggetto. Capacità di partecipare, utilizzando le conoscenze acquisite nel corso, alle iniziative di aggiornamento continuo nell’ambito professionale.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Teaching

The course includes frontal lessons (delivered simultaneously also in telematic mode) in which the teacher explains the fundamental concepts and provides practical examples to promote understanding. Students are encouraged to participate during the lessons both to ask for clarifications to the teacher and to provide further insights or topics of their interest.

Attendance

none

Assessment

none

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

The course includes frontal lessons (delivered simultaneously also in telematic mode) in which the teacher explains the fundamental concepts and provides practical examples to promote understanding. Students are encouraged to participate during the lessons both to ask for clarifications to the teacher and to provide further insights or topics of their interest.

Attendance

none

Course books

none

Assessment

Test prepared by the teacher

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.