Te couse aims to provide the molecular basis for understanding  the mechanisms of cell damage following exposure to etiological agents as well as the defensive mechanisms implemented by human organism. The course provides the notions and terms necessary to interact with different professional figures working in the healthcare field

The course will address the following topics in the order below.

 Definition of homeostasis

Elements of environmental diseases. Physical agents as cause of disease 

Chemical agents as cause of disease. Reactive oxygen species, oxidative stress and antioxidant systems

Etiological agents of biological nature: prions, viruses, bacteria, protozoa, fungi and helminths

Mechanisms of cellular damage.  Cell death : apoptosis and necrosis

Innate immunity : cells , receptors and mechanisms of action

Activation of inflammation

Leukocyte recruitment, chemotaxis and complement system

 Mediators of inflammation

Phagocytosis

Systemic manifestations of inflammation   

Acquired immunity : lymphocytes and cellular basis of adaptive immunity

Lymphocytes B and antibodies 

Generation of antibody diversity

  MHC proteins

Helper T Lymphocytes  

Cytotoxic T Lymphocyte

Intestinal microbiota in health and in pathological conditions

Interaction between muscle and immunity cells in muscle regeneration

None

Knowledge and understanding. The student must demonstrate that the basic knowledge regarding the defense mechanisms adopted by the human organism in response to various harmful stimuli are acquired

Applied knowledge and understanding. The student must demonstrate an understanding of the concepts and  the ability to transfer the acquired concepts into the practical activity 

Making judgements. The student must demonstrate the ability to use knowledge and concepts in the planning of personalized programs of functional re-education considering the characteristics and clinical condition of the patient.

Communication skills. The student must show the possession of the communication skills, using the correct terminology and must be able to interface with other professional figures operating in the health sector

Learning skills. The student must be able to build his path of scientific growth in a critical and autonomous way, being able to correctly use the study material recommended by the teacher as well as the in-depth material that he can procure himself. These skills will be stimulated by the teacher who will propose insights on topics of interest

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Seminar held by external lectures are foreseen.

During the course, self-assessment tests will be proposed 

Teaching

Front lessons

Innovative teaching methods

Flipped learning. The teacher selects scientific pubblications on topics that will be studied in dept. Each student will report the salient aspect of assigned pubblication to the class group and then the topic will be discussed

Attendance

No

Course books

Patologia generale e fisiopatologia generale Pontieri , Russo, Frati V Ed. Piccin Nuova Libraria  2015 Introduction to the Course (Chapter 1). Elements of environmental diseases (Chapter 4).  Mechanisms of cellular damage, ROS (chapter 6) . Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15).   

Immunologia  Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation . 

Other additional material will be available in the platform Moodle

Assessment

The assessment of learning includes an oral exam in which the student will have to answer 3 open questions. The evaluation will be formulated according to the following criteria:

less than 18: skill level not enough 

18-20: skill level enough 

21-23: skill level satisfactory

24-26: skill level good

27-29: skill level very good •

30-30 with honors: skill level excellent

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

The same of attending students

Attendance

No

Course books

Patologia generale e fisiopatologia generale Pontieri , Russo, Frati V Ed. Piccin Nuova Libraria  2015 Introduction to the Course (Chapter 1). Elements of environmental diseases (Chapter 4).  Mechanisms of cellular damage, ROS (chapter 6) . Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15).   

Immunologia  Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation . 

Other additional material will be available in the platform Moodle

Assessment

The assessment of learning includes an oral exam in which the student will have to answer 3 open questions. The evaluation will be formulated according to the following criteria:

less than 18: skill level not enough 

18-20: skill level enough 

21-23: skill level satisfactory

24-26: skill level good

27-29: skill level very good •

30-30 with honors: skill level excellent

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.