MOLECULAR PATHOLOGY AND LABORATORY
PATOLOGIA MOLECOLARE E DI LABORATORIO
| A.Y. | Credits |
|---|---|
| 2024/2025 | 6 |
| Lecturer | Office hours for students | |
|---|---|---|
| Mirco Fanelli | please contact the lecturer - mirco.fanelli@uniurb.it |
| Teaching in foreign languages |
|---|
|
Course partially taught in a foreign language
English
This course is taught partially in Italian and partially in a foreign language. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language. |
Assigned to the Degree Course
| Date | Time | Classroom / Location |
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| Date | Time | Classroom / Location |
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Learning Objectives
The objective of the Molecular Pathology and Laboratory course is to consider the pathology from a molecular point of view. Students will acquire informations concerning the altered molecular patterns - in different models of disease (focusing the neoplastic diseases) - with particular attention to genetic/epigenetic mechanisms . Additionally, several experimental approaches will be considered to study the most relevant biological processes (e.g. apoptosis, gene expression, epigenetic profiles, etc.)
Program
- The control of DNA stability: repair versus mutation
- Cell death: Apoptosis, Necrosis, and Autophagy
- Cellular senescence, Telomeres and cancer stem cells
- Experimental procedures for senescence/cell death identification
- Oncogenes and Signaling transduction
- Tumor suppressor genes and growth inhibition
- Celle cycle regulation and methods of study
- Regulation of the gene expression: from transcription factors to
chromatin structure
- Experimental approaches for gene expression studies
- Cancer epigenetics: DNA methylation.
- Methods for epigenetic studies
- The paradoxical model of APL: mechanisms, diagnosis, and therapy.
Bridging Courses
none
Learning Achievements (Dublin Descriptors)
Knowledge and understanding - Acquisition of the tools to understand the molecular mechanisms of disease. Ability to use the language of their specific discipline.
Applying knowledge and understanding - Ability to recognize and apply the cognitive tools and the rigorous approach of the Molecular Pathology as rational of any activity related directly and indirectly to health protection.
Indipendence of judgment - Being able to learn and independently evaluate the results of investigations on the pathogenesis and diagnosis of diseases
Communicative skills ?- Ability to explain, in a simple, immediate and exhaustive manner the acquired knowledge and to know how to interface with future professional roles (researchers, students, health-operative).
Learning ability - Upgrade capabilities through consultation of the scientific literatue of the discipline. Ability to participate, using the knowledge gained in the course, the continuous updating initiatives in the professional field.
Teaching Material
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
Supporting Activities
Lectures will be available online on the official site "blended learning"
Teaching, Attendance, Course Books and Assessment
- Teaching
Lectures and hands-on lab experiences
- Attendance
attendance at hands-on laboratory experiences is suggested
- Course books
1) Stella Pelengaris and Michael Khan - THE MOLECULAR BIOLOGY OF CANCER – 2° Edition
2) Mendelsohn, Gray, Howley, Israel and Thompson– THE MOLECULAR BASIS OF CANCER – 4° Edition
- Assessment
Oral examination
- Disability and Specific Learning Disorders (SLD)
Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.
To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.
Additional Information for Non-Attending Students
- Teaching
Lectures and hands-on lab experiences
- Attendance
attendance at hands-on laboratory experiences is suggested
- Course books
1) Stella Pelengaris and Michael Khan - THE MOLECULAR BIOLOGY OF CANCER – 2° Edition
2) Mendelsohn, Gray, Howley, Israel and Thompson– THE MOLECULAR BASIS OF CANCER – 4° Edition
- Assessment
Oral examination
- Disability and Specific Learning Disorders (SLD)
Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.
To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.
Notes
none
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