The objective of the Molecular Pathology and Laboratory course is to consider the pathology from a molecular point of view. Students will acquire informations concerning the altered molecular patterns - in different models of disease (focusing the neoplastic diseases) - with particular attention to genetic/epigenetic mechanisms  . Additionally, several experimental approaches will be considered to study the most relevant biological processes (e.g. apoptosis, gene expression, epigenetic profiles, etc.)

- The control of DNA stability: repair versus mutation

- Cell death: Apoptosis, Necrosis, and Autophagy

- Cellular senescence, Telomeres and cancer stem cells

- Experimental procedures for senescence/cell death identification

- Oncogenes and Signaling transduction

- Tumor suppressor genes and growth inhibition

- Celle cycle regulation and methods of study

- Regulation of the gene expression: from transcription factors to  

  chromatin structure

- Experimental approaches for gene expression studies

- Cancer epigenetics: DNA methylation.

- Methods for epigenetic studies

- The paradoxical model of APL: mechanisms, diagnosis, and therapy.

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Knowledge and understanding - Acquisition of the tools to understand the molecular mechanisms of disease. Ability to use the language of their specific discipline.

Applying knowledge and understanding - Ability to recognize and apply the cognitive tools and the rigorous approach of the  Molecular Pathology as rational of any activity related directly and indirectly to health protection.

Indipendence of judgment - Being able to learn and independently evaluate the results of investigations on the pathogenesis and diagnosis of diseases

Communicative skills ?- Ability to explain, in a simple, immediate and exhaustive manner the acquired knowledge and to know how to interface with future professional roles (researchers, students, health-operative).

Learning ability - Upgrade capabilities through consultation of the scientific literatue of the discipline. Ability to participate, using the knowledge gained in the course, the continuous updating initiatives in the professional field.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Lectures will be available online on the official site "blended learning" 

Teaching

Lectures and hands-on lab experiences

Attendance

attendance at hands-on laboratory experiences is suggested

Course books

1) Stella Pelengaris and Michael Khan - THE MOLECULAR BIOLOGY OF CANCER – 2° Edition

2) Mendelsohn, Gray, Howley, Israel and Thompson– THE MOLECULAR BASIS OF CANCER – 4° Edition

Assessment

Oral examination. During the examination the student must demonstrate: that it has acquired full mastery of the concepts covered during the course; to be able to make logical connections between the techniques learned and their applications; to be able to illustrate the key concepts in a limited time and using appropriate scientific language.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

Lectures and hands-on lab experiences

Attendance

attendance at hands-on laboratory experiences is suggested

Course books

1) Stella Pelengaris and Michael Khan - THE MOLECULAR BIOLOGY OF CANCER – 2° Edition

2) Mendelsohn, Gray, Howley, Israel and Thompson– THE MOLECULAR BASIS OF CANCER – 4° Edition

Assessment

Oral examination. During the examination the student must demonstrate: that it has acquired full mastery of the concepts covered during the course; to be able to make logical connections between the techniques learned and their applications; to be able to illustrate the key concepts in a limited time and using appropriate scientific language.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

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