Gian Marco Elisi / Ricercatore Legge 240/10 a tempo determinato

Gian Marco Elisi is a Post-doctoral Researcher (RTD-A) and Lecturer in Medicinal Chemistry at the University of Urbino and he is currently employed in the supervision of the VITALITY HPC platform. He graduated in Pharmaceutical Chemistry and Technology at the University of Modena and Reggio Emilia in 2019 and obtained the PhD title in the Drug Sciences doctoral program of the University of Parma in 2023. In the same year, he also joined Evotec as Senior Scientist. His research activies revolve around computational medicinal chemistry, in particular free-energy simulations for perspective drug design and the application of virtual screening protocols applied to ultra-large libraries.

Bedini A, Elisi GM, Fanini F, Retini M, Scalvini L, Pasquini S, Contri C, Varani K, Spadoni G, Mor M, Vincenzi F, Rivara S. “Binding and unbinding of potent melatonin receptor ligands: mechanistic simulations and experimental evidence”. J. Pineal Res., 2024, 76, 2, e12941.

Caputo A, Sartini S, Levati E, Minato I, Elisi GM, Di Stasi A, Guillou C, Goekjian PG, Garcia P, Gueyrard D, Bach S, Comte A, Ottonello S, Rivara S, Montanini B. “An optimized pipeline for the discovery of new antimicrobial compounds targeting bacterial RNA polymerase complex formation”. Antibiotics, 2022, 11, 10, 1449.

Mari M, Elisi GM, Bedini A, Lucarini S, Retini M, Lucini V, Scaglione F, Vincenzi F, Varani K, Castelli R, Mor M, Rivara S, Spadoni G. “Melatonin analogues probing the 2-phenyl-binding pocket reveal tolerance to hydrophilic groups”. Eur J Med Chem, 2022, 243, 14762.

Elisi GM, Scalvini L, Lodola A, Bedini A, Spadoni G, Rivara S. “In silico drug discovery of melatonin receptor ligands with therapeutic potential”. Expert Opin Drug Discov., 2022, 17, 4, 343-54.

Lauriola A, Uliassi E, Santucci M, Bolognesi ML, Mor M, Scalvini L, Elisi GM, Gozzi G, Tagliazucchi L, Marverti G, Ferrari S, Losi L, D’Arca D, Costi MP. “Identification of a quinone derivative as YAP/TEAD activity modulator from a repurposing library”. Pharmaceutics 2022, 14, 2, 391.

Elisi GM, Scalvini L, Lodola A, Mor M, Rivara S. “Free-energy simulations support a lipophilic binding route for melatonin receptors”. J Chem Inf Model. 2022, 62, 1, 210-22.

Ferlenghi F, Mari M, Gobbi G, Elisi GM, Mor M, Rivara S, Vacondio F, Bartolucci S, Bedini A, Fanini F, Spadoni G, “N-(anilinoethyl)amide melatonergic ligands with improved water solubility and metabolic stability” ChemMedChem. 2021, 16, 19, 3071.

Elisi GM, Bedini A, Scalvini L, Carmi C, Bartolucci S, Lucini V, Scaglione F, Mor M, Rivara S, Spadoni G, “Chiral recognition of flexible melatonin receptor ligands induced by conformational equilibria”, Molecules 2020, 4, 25, 4057.

Pala D, Scalvini L, Elisi GM, Lodola A, Mor M, Spadoni G, Ferrara FF, Pavoni E, Roscilli G, Milazzo FM, Battistuzzi G, Rivara S, Giannini G, “New classes of potent heparanase inhibitors from ligand-based virtual screening”, J Enzyme Inhib Med Chem 2020, 35, 1, 1685-96.

Elisi GM, Santucci M, D'Arca D, Lauriola A, Marverti G, Losi L, Scalvini L, Bolognesi ML, Mor M, Costi MP, “Repurposing of drugs targeting YAP-TEAD functions”, Cancers, 2018, 10, 9, 329.