Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


Struttura
Dipartimento di Scienze Biomolecolari (DISB) Urbino Piazza Rinascimento, 6 0722 303333 simone.lucarini@uniurb.it
Sito web

During his scientific activity, Prof. Lucarini carried out research in the fields of Medicinal, Supramolecular, and Organic Chemistry in order to obtain new original methods for obtaining achiral and chiral molecules of pharmaceutical-biological interest, together with the development of new synthetic methods of potential industrial interest. In detail, during his undergrad thesis (Bologna), he did research in the field of foldamers, new oligomers with predictable three-dimensional structures with high biological activity. During his doctoral thesis (Urbino and Kansas, USA), he worked on the design, synthesis, and study of the anionic and cationic binding properties of new macrocycles for biological applications such as imaging for medical diagnostics. He then started working on the design and synthesis of diastero- and enantioselective ligands for melatonergic receptors. During the post-doc period in Tokyo (Japan), coinciding with the "avian pandemic", he developed a new synthetic method that is plausibly applicable to the production of (-) - shikimic acid, a key intermediate for the synthesis of Tamiflu, starting from achiral reagents and readily available on the market. Then, he developed new methodologies for the synthesis of natural products, containing the indole nucleus, with potential antitumor activity. Recently, he started a new and promising research line concerning the design and synthesis of new glycolipid for pharmaceutical/medicinal applications. In the last couple of years, he has been expanding the biological application of bisindoles, and in particular to the treatment of Leishmaniasis.

68) Alessia Centanni, Aurora Diotallevi, Gloria Buffi, Diego Olivieri, Nuno Santarém, Antti Lehtinen, Jari Yli-Kauhaluoma, Anabela Cordeiro-da-Silva, Paula Kiuru, Simone Lucarini*, Luca Galluzzi, PLoS ONE 2024, 19 (6), e0301901; “Exploring hydrophilic 2,2-di(indol-3-yl)ethanamine derivatives against Leishmania infantum”. IF = 3.7, Q2 in Multidisciplinary Sciences (2022)

 67) Vittorio Ciccone, Aurora Diotallevi, Miriam Gómez-Benmansour, Sara Maestrini, Fabio Mantellini, Giacomo Mari, Luca Galluzzi, Simone Lucarini* and Gianfranco Favi; RSC Advances 2024, 14, 15713-15720; “Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents”. IF = 3.9, Q2 in Multidisciplinary Chemistry (2022)

 66) Diego Olivieri, Michele Verboni, Riccardo Tarroni, Stefano Zacchini, Simone Lucarini, Nicola Della Ca, Raffaella Mancuso, Bartolo Gabriele and Carla Carfagna; Journal of Catalysis 2024, 432, 115397; “Versatile stereoselective oxidative alkoxycarbonylation of styrenes at room-temperature”. IF = 7.3, Q1 in Physical Chemistry (2022)

65) Mattia Tiboni, Paola Astolfi, Michele Verboni, Serena Benedetti, Elisabetta Giorgini, Valentina Notarstefano, Francesco Vita, Simone Ranieri, Andrea Duranti, Simone Lucarini, Luca Casettari and Michela Pisani; Colloids and Surfaces B: Biointerfaces 2023, 232, 113596; “The influence of mannose-based esters on the mesophase behaviour of lyotropic liquid crystalline nanosystems as drug delivery vectors”. IF = 5.8, Q1 in Biophysics (2022)

64) Michele Verboni, Diego Romano Perinelli, Alessandro Buono, Raffaella Campana, Maurizio Sisti, Andrea Duranti and Simone Lucarini; Antibiotics 2023, 12 (10), 1500; “Sugar-Based Monoester Surfactants: Synthetic Methodologies, Properties, and Biological Activities”. IF = 4.8, Q1 in Pharmacology & Pharmacy (2022)

63) Federica Centofanti, Alessandro Buono, Michele Verboni, Carlo Tomino, Simone Lucarini, Andrea Duranti, Pier Paolo Pandolfi and Giuseppe Novelli; Pharmaceuticals 2023, 16 (2), 240; “Synthetic Methodologies and Therapeutic Potential of Indole-3-Carbinol (I3C) and Its Derivatives”. IF = 4.6, Q2 in Medicinal Chemistry (2022)

62) Michele Verboni, Diego Romano Perinelli, Carol Yingshan Qiu, Mattia Tiboni, Annalisa Aluigi, Simone Lucarini*, Jenny K. W. Lam and Andrea Duranti; Pharmaceuticals 2023, 16 (2), 223; “Synthesis and Properties of Sucrose- and Lactose-Based Aromatic Ester Surfactants as Potential Drugs Permeability Enhancers”. IF = 4.6, Q2 in Medicinal Chemistry (2022)

61) Michele Verboni, Maurizio Sisti, Raffaella Campana, Serena Benedetti, Francesco Palma, Lucia Potenza, Simone Lucarini* and Andrea Duranti; Pharmaceuticals 2023, 16 (2), 136; “Synthesis and Biological Evaluation of 6-O-Sucrose Monoester Glycolipids as Possible New Antifungal Agents”. IF = 4.6, Q2 in Medicinal Chemistry (2022)

Prodotti della Ricerca di Simone Lucarini.

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Insegnamento
Course
2024/2025 ANALISI DEI FARMACI QUANTITATIVA CON LABORATORIO
QUANTITATIVE DRUG ANALYSIS AND LABORATORY
Course with optional materials in a foreign language
2024/2025 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
Course partially taught in a foreign language
2024/2025 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2024/2025 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2024/2025 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2023/2024 ANALISI DEI MEDICINALI I
Drug Analysis I
Course with optional materials in a foreign language
2023/2024 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
Course with optional materials in a foreign language
2023/2024 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2023/2024 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2023/2024 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2023/2024 QUANTITATIVE AND QUALITATIVE METHODOLOGIES IN CHEMICAL RESEARCH (MOD. 2)
QUANTITATIVE AND QUALITATIVE METHODOLOGIES IN CHEMICAL RESEARCH (MOD. 2)
Course entirely taught in a foreign language
2022/2023 ANALISI DEI MEDICINALI I
Drug Analysis I
Course with optional materials in a foreign language
2022/2023 MOLECULAR STRUCTURE DETERMINATION
MOLECULAR STRUCTURE DETERMINATION
Course entirely taught in a foreign language
2022/2023 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
Course with optional materials in a foreign language
2022/2023 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2022/2023 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
Course with optional materials in a foreign language
2021/2022 ANALISI DEI MEDICINALI I
Drug Analysis I
Course with optional materials in a foreign language
2021/2022 MOLECULAR STRUCTURE DETERMINATION
MOLECULAR STRUCTURE DETERMINATION
Course entirely taught in a foreign language
2021/2022 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
Course with optional materials in a foreign language
2021/2022 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
2021/2022 PRODOTTI NATURALI IN CHIMICA FARMACEUTICA
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY
mutuato
2020/2021 ANALISI DEI MEDICINALI I
Drug Analysis I
Course with optional materials in a foreign language
2019/2020 ANALISI DEI MEDICINALI I
Drug Analysis I
Course with optional materials in a foreign language
2018/2019 ANALISI DEI MEDICINALI I
Drug Analysis I
Course with optional materials in a foreign language
2018/2019 ANALISI DEI MEDICINALI II
Drug Analysis II
Course with optional materials in a foreign language
2017/2018 ANALISI DEI MEDICINALI II
Drug Analysis II
Course with optional materials in a foreign language
2016/2017 ANALISI DEI MEDICINALI II
Drug Analysis II
Course with optional materials in a foreign language
2015/2016 ANALISI DEI MEDICINALI II
Drug Analysis II
2014/2015 Analisi dei medicinali II
2013/2014 Analisi dei medicinali II
2012/2013 Analisi dei medicinali II
2011/2012 Analisi dei medicinali I
2010/2011 Analisi dei medicinali I
2009/2010 Analisi dei medicinali I
2008/2009 Analisi dei medicinali I
Giorno Orario Attività Aula

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